Volume 8 Supplement 1

Molecular Neurodegeneration: Basic biology and disease pathways

Open Access

The dishomeostasis of metal ions plays an important role for the cognitive impartment

  • Dehua Chui1, 3,
  • Huan Yang1,
  • Hecheng Wang1,
  • Tuo JI1,
  • Jia Yu1, 2,
  • Shouzi Zhang2,
  • Zheng Chen2 and
  • WeiZhong Xiao3
Molecular Neurodegeneration20138(Suppl 1):P13

DOI: 10.1186/1750-1326-8-S1-P13

Published: 13 September 2013

Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer’s disease (AD) and might underlie memory impairment. The homeostasis of metal ions plays an important role in health and neurodegenerative disease by influencing cellular biochemical pathways. The disturbance of some metal ions may have cytotoxic effects, which may cause cell death leading to neurodegenerative disorders such as AD. The aim of the present study was to investigate metal concentrations in whole blood from Chinese AD patients with APOE ε4 allele carrier. Concentrations of metals (magnesium, calcium, manganese, iron, cobalt, copper, zinc, selenium, cadmium, mercury and lead) were determined in whole blood by inductively coupled plasma mass spectrometry (ICP-MS) in 40 Chinese people with different Mini-mental state examination (MMSE) score. Normal APP processing could be restored when magnesium was adjusted back to physiological concentration. Our findings suggest that supplementation of magnesium has a therapeutic potential for preventing AD. We observed that Plasma Mg, Zn and Se levels were found to be significantly lower in patients with AD compared with controls. Furthermore, there is a significant negative correlation between manganese and MMSE score. Whereas other metal ions have no association with MMSE score. These result suggests that dishomeostasis of metal ions may involve in the progress of AD pathology, and elevation of brain magnesium exerts substantial synaptoprotective effects in a mouse model of AD and may have therapeutic potential for treating AD in humans.



This work was supported by 973 Program No.2012CB911004 and the NSFC Grants No.No.81171015.

Authors’ Affiliations

Neuroscience Research Institute, Health Science Center, Peking University
Beijing Geriatric Hospital
Department of Neurology, Peking University Third Hospital


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© Chui et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.