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  1. Research article

    Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

    The activation of the aspartate-specific cysteinyl protease, Caspase-6, is proposed as an early pathogenic event of Alzheimer disease (AD) and Huntington’s disease. Caspase-6 inhibitors could be useful against...

    Prateep Pakavathkumar, Anastasia Noël, Clotilde Lecrux, Agne Tubeleviciute-Aydin, Edith Hamel, Jan-Eric Ahlfors and Andrea C. LeBlanc

    Molecular Neurodegeneration 2017 12:22

    Published on: 28 February 2017

  2. Research article

    Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

    Reduction or inhibition of histone deacetylase 6 (HDAC6) has been shown to rescue memory in mouse models of Alzheimer’s disease (AD) and is recently being considered a possible therapeutic strategy. However, t...

    Heesun Choi, Haeng Jun Kim, Jisoo Kim, Soohyun Kim, Jinhee Yang, Wonik Lee, Yeonju Park, Seung Jae Hyeon, Dong-Sup Lee, Hoon Ryu, Junho Chung and Inhee Mook-Jung

    Molecular Neurodegeneration 2017 12:23

    Published on: 28 February 2017

  3. Research article

    Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

    The ubiquitin-proteasome-system (UPS) is the major intracellular pathway leading to the degradation of unwanted and/or misfolded soluble proteins. This includes proteins regulating cellular survival, synaptic ...

    Tobias Engel, Jaime Martinez-Villarreal, Christine Henke, Eva M. Jimenez-Mateos, Amaya Sanz-Rodriguez, Mariana Alves, Yasmina Hernandez-Santana, Gary P. Brennan, Aidan Kenny, Aoife Campbell, Jose J. Lucas and David C. Henshall

    Molecular Neurodegeneration 2017 12:21

    Published on: 24 February 2017

  4. Research article

    Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination

    The ability of oligodendrocyte progenitor cells (OPCs) to give raise to myelin forming cells during developmental myelination, normal adult physiology and post-lesion remyelination in white matter depends on f...

    Camille Leonetti, Richard Macrez, Mathilde Pruvost, Yannick Hommet, Jérémie Bronsard, Antoine Fournier, Maxime Perrigault, Isabel Machin, Denis Vivien, Diego Clemente, Fernando De Castro, Eric Maubert and Fabian Docagne

    Molecular Neurodegeneration 2017 12:20

    Published on: 23 February 2017

  5. Research article

    Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway

    Proteolytic degradation of amyloid β (Aβ) peptides has been intensely studied due to the central role of Aβ in Alzheimer’s disease (AD) pathogenesis. While several enzymes have been shown to degrade Aβ peptide...

    Erik Portelius, Niklas Mattsson, Josef Pannee, Henrik Zetterberg, Magnus Gisslén, Hugo Vanderstichele, Eleni Gkanatsiou, Gabriela A. N. Crespi, Michael W. Parker, Luke A. Miles, Johan Gobom and Kaj Blennow

    Molecular Neurodegeneration 2017 12:18

    Published on: 20 February 2017

  6. Review

    Tau PET imaging: present and future directions

    Abnormal aggregation of tau in the brain is a major contributing factor in various neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of tauopathies remains unclear. Consequentl...

    Laure Saint-Aubert, Laetitia Lemoine, Konstantinos Chiotis, Antoine Leuzy, Elena Rodriguez-Vieitez and Agneta Nordberg

    Molecular Neurodegeneration 2017 12:19

    Published on: 20 February 2017

  7. Research article

    Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice

    Reactive microglia have been associated with the histological changes that occur in Parkinson’s disease brains and mouse models of the disease. Multiple studies from autopsy brains have verified the presence o...

    Gunjan Dhawan Manocha, Angela Marie Floden, Kendra Lynn Puig, Kumi Nagamoto-Combs, Clemens R. Scherzer and Colin Kelly Combs

    Molecular Neurodegeneration 2017 12:17

    Published on: 14 February 2017

  8. Research article

    Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

    Alzheimer’s disease (AD)-linked protein, presenilin 1 (PS1), is present at the synapse, and the knock-out of presenilin in mice leads to synaptic dysfunction. On the other hand, synaptic activity was shown to ...

    Katarzyna Marta Zoltowska, Masato Maesako, Iryna Lushnikova, Shuko Takeda, Laura J. Keller, Galina Skibo, Bradley T. Hyman and Oksana Berezovska

    Molecular Neurodegeneration 2017 12:15

    Published on: 13 February 2017

  9. Research article

    Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration

    Neuroinflammation is associated with a wide range of neurodegenerative disorders, however the specific contribution to individual disease pathogenesis and selective neuronal cell death is not well understood. ...

    Michael Lattke, Stephanie N. Reichel, Alexander Magnutzki, Alireza Abaei, Volker Rasche, Paul Walther, Dinis P. Calado, Boris Ferger, Thomas Wirth and Bernd Baumann

    Molecular Neurodegeneration 2017 12:16

    Published on: 13 February 2017

  10. Research article

    Tdp-43 cryptic exons are highly variable between cell types

    TDP-43 proteinopathy is a prominent pathological feature that occurs in a number of human diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and inclusion body myositis (IBM...

    Yun Ha Jeong, Jonathan P. Ling, Sophie Z. Lin, Aneesh N. Donde, Kerstin E. Braunstein, Elisa Majounie, Bryan J. Traynor, Katherine D. LaClair, Thomas E. Lloyd and Philip C. Wong

    Molecular Neurodegeneration 2017 12:13

    Published on: 2 February 2017

  11. Research article

    APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

    APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer’s disease (AD). Here we investigated how APOE genotype influences respo...

    Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, Jennifer Lopez-Contreras, Jungsu Kim, Patrick M. Sullivan, David M. Holtzman and Martin J. Sadowski

    Molecular Neurodegeneration 2017 12:12

    Published on: 31 January 2017

  12. Review

    Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease

    Converging evidence from genetic, pathological and experimental studies have increasingly suggested an important role for autophagy impairment in Parkinson’s Disease (PD). Genetic studies have identified mutat...

    Tim E. Moors, Jeroen J. M. Hoozemans, Angela Ingrassia, Tommaso Beccari, Lucilla Parnetti, Marie-Christine Chartier-Harlin and Wilma D. J. van de Berg

    Molecular Neurodegeneration 2017 12:11

    Published on: 25 January 2017

  13. Research article

    GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord

    Glycerophosphodiester phosphodiesterase 2 (GDE2) is a six-transmembrane protein that cleaves glycosylphosphatidylinositol (GPI) anchors to regulate GPI-anchored protein activity at the cell surface. In the dev...

    Clinton Cave, Sungjin Park, Marianeli Rodriguez, Mai Nakamura, Ahmet Hoke, Mikhail Pletnikov and Shanthini Sockanathan

    Molecular Neurodegeneration 2017 12:8

    Published on: 19 January 2017

  14. Research article

    Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

    LRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson’s disease, while recent studies have identified potential protective variants. This, and...

    Daniel C. Berwick, Behzad Javaheri, Andrea Wetzel, Mark Hopkinson, Jonathon Nixon-Abell, Simone Grannò, Andrew A. Pitsillides and Kirsten Harvey

    Molecular Neurodegeneration 2017 12:9

    Published on: 19 January 2017

  15. Review

    NADPH oxidase in brain injury and neurodegenerative disorders

    Oxidative stress is a common denominator in the pathology of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple scle...

    Merry W. Ma, Jing Wang, Quanguang Zhang, Ruimin Wang, Krishnan M. Dhandapani, Ratna K. Vadlamudi and Darrell W. Brann

    Molecular Neurodegeneration 2017 12:7

    Published on: 17 January 2017

  16. Research article

    Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration

    The most frequent genetic cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) is the expansion of a GGGGCC hexanucleotide repeat in a non-coding region of the chromosome 9...

    Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer and Bettina Schmid

    Molecular Neurodegeneration 2017 12:6

    Published on: 14 January 2017

  17. Research article

    The release and trans-synaptic transmission of Tau via exosomes

    Tau pathology in AD spreads in a hierarchical pattern, whereby it first appears in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding areas. Based on this sequential appearance...

    Yipeng Wang, Varun Balaji, Senthilvelrajan Kaniyappan, Lars Krüger, Stephan Irsen, Katharina Tepper, RamReddy Chandupatla, Walter Maetzler, Anja Schneider, Eckhard Mandelkow and Eva-Maria Mandelkow

    Molecular Neurodegeneration 2017 12:5

    Published on: 13 January 2017

  18. Erratum

    Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

    Thiyagaragan M. Achariyar, Baoman Li, Weiguo Peng, Philip B. Verghese, Yang Shi, Evan McConnell, Abdellatif Benraiss, Tristan Kasper, Wei Song, Takahiro Takano, David M. Holtzman, Maiken Nedergaard and Rashid Deane

    Molecular Neurodegeneration 2017 12:3

    Published on: 12 January 2017

    The original article was published in Molecular Neurodegeneration 2016 11:74

  19. Research article

    Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

    Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) gene cause a familial form of amyotrophic lateral sclerosis (SOD1-ALS) with accumulation of misfolded SOD1 proteins as intracellular inclusions in spinal mo...

    Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa and Yoshiaki Furukawa

    Molecular Neurodegeneration 2017 12:2

    Published on: 5 January 2017

  20. Research article

    Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

    Cell-to-cell transmission of α-synuclein (αSyn) is hypothesized to play an important role in disease progression in synucleinopathies. This process involves cellular uptake of extracellular amyloidogenic αSyn ...

    Emily J. Koller, Mieu M. T. Brooks, Todd E. Golde, Benoit I. Giasson and Paramita Chakrabarty

    Molecular Neurodegeneration 2017 12:1

    Published on: 3 January 2017

  21. Research article

    ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models

    Autophagy is a bulk degradation pathway for long-lived proteins, protein aggregates, and damaged organelles. ULK1 protein kinase and Vps34 lipid kinase are two key autophagy regulators that are critical for au...

    Mitchell S. Wold, Junghyun Lim, Véronik Lachance, Zhiqiang Deng and Zhenyu Yue

    Molecular Neurodegeneration 2016 11:76

    Published on: 9 December 2016

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