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Editors' Highlights

2021 Research Highlights

As the field’s leading Open Access neuroscience journal, Molecular Neurodegeneration showcases research focusing on the molecular and cellular mechanisms underlying neurodegenerative diseases.

Now in our 16th year of publication, our Editors would like to share a selection of recent article highlights.

New Content ItemAPOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

Brandon C. Farmer, Holden C. Williams, […], Lance A. Johnson


New Content ItemSex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains

Julio Barrera, Lingyun Song, […], Ornit Chiba-Falek

New Content ItemDecoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

Laura Pasetto, Stefano Callegaro, […], Valentina Bonetto

New Content ItemPlaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

Christel Claes, Emma Pascal Danhash, […], Mathew Blurton-Jones

New Content ItemPost-infection cognitive impairments in a cohort of elderly patients with COVID-19

Yu-Hui Liu, Ye-Ran Wang, […], Yan-Jiang Wang

New Content ItemAccumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

Md Golam Sharoar, Sarah Palko, […], Riqiang Yan

New Content ItemAMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

Nicolas Belforte, Jessica Agostinone, […], Adriana Di Polo

New Content ItemParkinson mice show functional and molecular changes in the gut long before motoric disease onset

Manuela Gries, Anne Christmann, […], Karl-Herbert Schäfer

New Content ItemOligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo

Souvarish Sarkar, Farah Bardai, […], Mel B. Feany

New Content ItemModulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy

Yona Levites, Cory Funk, […], Todd E. Gold

New Content ItemCalcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

Shaowei Wang, Boyang Li, […], Hussein N. Yassine

Molecular Neurodegeneration is the official journal of the BrightFocus Foundation.


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