Figure 3

Sepp1 (-/-) mice exhibit normal associative conditioned fear learning and memory. (A) Freezing during the two trial, paired conditioned stimulus (CS: 85dB tone represented by black line) and unconditioned stimulus (US: 0.5mA foot shock represented by the arrow) training paradigm. Both genotypes respond comparably to training (n = 16 mice per genotype). (B) Freezing during the context tests (2.5 min) performed 2 hrs and 24 hrs post training. Both genotypes learned to associate the context with the US equally well. (C) Freezing during the cued tests performed 2 hrs and 24 hrs post training. Both genotypes learned to associate the CS with the US equally well. Graph shows the % increase in freezing to the CS compared to baseline freezing before presentation of the CS. (D) Freezing during the context test (8 min) performed 1 week post training. Both genotypes exhibited long-term memory for association of the context with the US.