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Table 1 Demographic characteristics and ABCB1 genotype, allele and haplotype frequencies (n, (%))

From: ABCB1genotypes and haplotypes in patients with dementia and age-matched non-demented control patients

  Total POP (n = 154) Controls (n = 41) AD (n = 48) VaD (n = 19) OD (n = 26) MCI (n = 20)
Age, Mean ± SD (range) 81.7 ± 5.9 (63.3–94.8) 81.9 ± 5.7 (69.5–94.5) 81.0 ± 5.5 (71.9–93.3) 83.6 ± 5.6 (67.6–89.7) 82.1 ± 5.2 (69.6–94.8) 80.5 ± 6.9 (63.3–90.7)
Gender, n (%) female 92 (59.7) 27 (65.9) 33 (68.8) 8 (42.1) 11 (42.3) 13 (65.0)
Education, median IQR (range) 4 IQR: 3 (1–7) 4 IQR:3 (1–6)* 4 IQR:3 (1–7) 5 IQR:2 (4–6) 4 IQR: 3 (2–7) 4 IQR:3 (2–6)*
Baseline MMSE, Mean ± SD (range) 21.2 ± 5.7 (3–30) 26.6 ± 2.2 (21–29) 18.2 ± 4.4†,§ (6–26)# 18.1 ± 7.5†,§ (3–29) 20.9 ± 5.2 (12–30) 25.3 ± 2.7 (19–30)
Ethnicity, n (%) CAU 151 (98.1) 40 (97.6) 48 (100) 19 (100) 25 (96.2) 19 (95.0)
SNP C1236T (12)       
   CC 44 (28.6) 12 (29.3) 12 (25.0) 3 (15.8) 7 (26.9) 10 (50.0)
   CT 75 (48.7) 20 (48.8) 25 (52.1) 10 (52.6) 14 (53.8) 6 (30.0)
   TT 35 (22.7) 9 (22.0) 11 (22.9) 6 (31.6) 5 (19.2) 4 (20.0)
   Allele freq T (%) 0.471 0.463 0.490 0.579 0.462 0.350
SNP G2677T/A (21)       
   GG 46 (29.9) 12 (29.3) 13 (27.1) 4 (21.2) 7 (26.9) 10 (50.0)
   GT 67 (43.5) 16 (39.0) 24 (50.0) 9 (47.4) 13 (50.0) 5 (25.0)
   TA 3 (1.9) 2 (4.9) 0 (0.0) 0 (0.0) 1 (3.8) 0 (0.0)
   TT 38 (24.7) 11 (26.8) 11 (22.9) 6 (31.6) 5 (19.2) 5 (25.0)
   Allele freq T (%) 0.474 0.488 0.479 0.553 0.462 0.375
   Allele freq A (%) 0.010 0.024 0.000 0.000 0.019 0.000
SNP C3435T (26)       
   CC 32 (20.8) 9 (22.0) 5 (10.4) 2 (10.5) 8 (30.8) 8 (40.0)
   CT 70 (45.5) 18 (43.9) 26 (54.2) 9 (47.4) 10 (38.5) 7 (35.0)
   TT 52 (33.8) 14 (34.1) 17 (35.4) 8 (42.1) 8 (30.8) 5 (25.0)
   Allele freq T (%) 0.565 0.561 0.625 0.658 0.500 0.425
Haplotype Total POPa (n = 148) Controls (n = 38) AD (n = 48) VaD (n = 19) OD (n = 24) MCI (n = 19)
   T-T-T 130 (0.439) 33 (0.434) 43 (0.448) 20 (0.526) 22 (0.458) 12 (0.316)
   C-G-C 114 (0.385) 29 (0.382) 34 (0.354) 11(0.289) 21 (0.438) 19 (0.500)
   C-G-T 38 (0.128) 10 (0.132) 15 (0.156) 5 (0.132) 4 (0.083) 4 (0.105)
   C-T-T 5 (0.017) 3 (0.039) 1 (0.010) 0 (0.000) 0 (0.000) 1 (0.026)
   T-G-C 4 (0.014) 1 (0.013) 2 (0.021) 1 (0.026) 0 (0.000) 0 (0.000)
   T-T-C 5 (0.017) 0 (0.000) 1 (0.001) 1 (0.026) 1 (0.021) 2 (0.053)
  1. * missing for 2 patients. missing for 1 patient. p < 0.001 vs. controls. §p < 0.001 vs. MCI performed in 22 controls. #missing for 3 patients.
  2. Haplotype of the different SNPs, i.e. number of alleles and frequencies of the haplotype mentioned. C1236T-G2677T-C3435T;a 3 patients with an ethnicity different from Caucasian and 3 patients bearing an A allele at the 2677 (exon 21) position were excluded from haplotype analysis. POP = Population, AD = Alzheimer's Disease, VaD = Vascular Dementia, OD = Other dementias, MCI = Mild Cognitive Impairment, SD = Standard Deviation, IQR = Inter Quartile Range, MMSE = Mini Mental State Examination, CAU = Caucasian race, SNP = Single Nucleotide Polymorphism.