| |
Total POP (n = 154)
|
Controls (n = 41)
|
AD (n = 48)
|
VaD (n = 19)
|
OD (n = 26)
|
MCI (n = 20)
|
|---|
|
Age, Mean ± SD (range)
|
81.7 ± 5.9 (63.3–94.8)
|
81.9 ± 5.7 (69.5–94.5)
|
81.0 ± 5.5 (71.9–93.3)
|
83.6 ± 5.6 (67.6–89.7)
|
82.1 ± 5.2 (69.6–94.8)
|
80.5 ± 6.9 (63.3–90.7)
|
|
Gender, n (%) female
|
92 (59.7)
|
27 (65.9)
|
33 (68.8)
|
8 (42.1)
|
11 (42.3)
|
13 (65.0)
|
|
Education, median IQR (range)
|
4 IQR: 3 (1–7)
|
4 IQR:3 (1–6)*
|
4 IQR:3 (1–7)†
|
5 IQR:2 (4–6)†
|
4 IQR: 3 (2–7)†
|
4 IQR:3 (2–6)*
|
|
Baseline MMSE, Mean ± SD (range)
|
21.2 ± 5.7 (3–30)
|
26.6 ± 2.2 (21–29)¶
|
18.2 ± 4.4†,§ (6–26)#
|
18.1 ± 7.5†,§ (3–29)
|
20.9 ± 5.2† (12–30)†
|
25.3 ± 2.7 (19–30)†
|
|
Ethnicity, n (%) CAU
|
151 (98.1)
|
40 (97.6)
|
48 (100)
|
19 (100)
|
25 (96.2)
|
19 (95.0)
|
|
SNP C1236T (12)
| | | | | | |
|
CC
|
44 (28.6)
|
12 (29.3)
|
12 (25.0)
|
3 (15.8)
|
7 (26.9)
|
10 (50.0)
|
|
CT
|
75 (48.7)
|
20 (48.8)
|
25 (52.1)
|
10 (52.6)
|
14 (53.8)
|
6 (30.0)
|
|
TT
|
35 (22.7)
|
9 (22.0)
|
11 (22.9)
|
6 (31.6)
|
5 (19.2)
|
4 (20.0)
|
|
Allele freq T (%)
|
0.471
|
0.463
|
0.490
|
0.579
|
0.462
|
0.350
|
|
SNP G2677T/A (21)
| | | | | | |
|
GG
|
46 (29.9)
|
12 (29.3)
|
13 (27.1)
|
4 (21.2)
|
7 (26.9)
|
10 (50.0)
|
|
GT
|
67 (43.5)
|
16 (39.0)
|
24 (50.0)
|
9 (47.4)
|
13 (50.0)
|
5 (25.0)
|
|
TA
|
3 (1.9)
|
2 (4.9)
|
0 (0.0)
|
0 (0.0)
|
1 (3.8)
|
0 (0.0)
|
|
TT
|
38 (24.7)
|
11 (26.8)
|
11 (22.9)
|
6 (31.6)
|
5 (19.2)
|
5 (25.0)
|
|
Allele freq T (%)
|
0.474
|
0.488
|
0.479
|
0.553
|
0.462
|
0.375
|
|
Allele freq A (%)
|
0.010
|
0.024
|
0.000
|
0.000
|
0.019
|
0.000
|
|
SNP C3435T (26)
| | | | | | |
|
CC
|
32 (20.8)
|
9 (22.0)
|
5 (10.4)
|
2 (10.5)
|
8 (30.8)
|
8 (40.0)
|
|
CT
|
70 (45.5)
|
18 (43.9)
|
26 (54.2)
|
9 (47.4)
|
10 (38.5)
|
7 (35.0)
|
|
TT
|
52 (33.8)
|
14 (34.1)
|
17 (35.4)
|
8 (42.1)
|
8 (30.8)
|
5 (25.0)
|
|
Allele freq T (%)
|
0.565
|
0.561
|
0.625
|
0.658
|
0.500
|
0.425
|
|
Haplotype
|
Total POPa (n = 148)
|
Controls (n = 38)
|
AD (n = 48)
|
VaD (n = 19)
|
OD (n = 24)
|
MCI (n = 19)
|
|
T-T-T
|
130 (0.439)
|
33 (0.434)
|
43 (0.448)
|
20 (0.526)
|
22 (0.458)
|
12 (0.316)
|
|
C-G-C
|
114 (0.385)
|
29 (0.382)
|
34 (0.354)
|
11(0.289)
|
21 (0.438)
|
19 (0.500)
|
|
C-G-T
|
38 (0.128)
|
10 (0.132)
|
15 (0.156)
|
5 (0.132)
|
4 (0.083)
|
4 (0.105)
|
|
C-T-T
|
5 (0.017)
|
3 (0.039)
|
1 (0.010)
|
0 (0.000)
|
0 (0.000)
|
1 (0.026)
|
|
T-G-C
|
4 (0.014)
|
1 (0.013)
|
2 (0.021)
|
1 (0.026)
|
0 (0.000)
|
0 (0.000)
|
|
T-T-C
|
5 (0.017)
|
0 (0.000)
|
1 (0.001)
|
1 (0.026)
|
1 (0.021)
|
2 (0.053)
|
- * missing for 2 patients. † missing for 1 patient. ‡p < 0.001 vs. controls. §p < 0.001 vs. MCI ¶performed in 22 controls. #missing for 3 patients.
- Haplotype of the different SNPs, i.e. number of alleles and frequencies of the haplotype mentioned. C1236T-G2677T-C3435T;a 3 patients with an ethnicity different from Caucasian and 3 patients bearing an A allele at the 2677 (exon 21) position were excluded from haplotype analysis. POP = Population, AD = Alzheimer's Disease, VaD = Vascular Dementia, OD = Other dementias, MCI = Mild Cognitive Impairment, SD = Standard Deviation, IQR = Inter Quartile Range, MMSE = Mini Mental State Examination, CAU = Caucasian race, SNP = Single Nucleotide Polymorphism.
