Figure 2
From: Pathological and physiological functions of presenilins
Multifaceted functions of PS1 mediated through the interacting proteins. The figure represents the multiple roles of PS1 in cellular functions. PS1 associates with nicastrin, APH-1 and PEN-2 to form the γ-secretase, which cleaves a set of type I membrane protein substrates including APP and Notch. Transmembrane proteins CD147 and p23/TMP21 have been shown to interact with γ-secretase complex and modulate Aβ production. In addition, PS1 interacts with several proteins that are involved in important physiological functions such as calcium homeostasis, vesicular transport, cell adhesion, etc. Trafficking of certain membrane proteins, including some γ-secretase substrates also seems to be influenced by PS1 deficiency, inhibition of γ-secretase activity, or expression of FAD-linked PS1 variants.