Compounds that reduce tau protein levels also affect mRNA expression. H4 cells were treated in triplicate with 10, 1, and 0.1 μM of compounds listed on x-axis. Quantitative real time PCR was used to determine expression levels of tau relative to GAPDH. Relative fluorescent units (RFUs) were determined and presented here as a percentage of the vehicle-treated controls. "NS" indicates no RFUs detected.