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Table 2 Therapeutic window for most favorable candidate compounds

From: Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

 

TC50 (μM)

IC (μM)

Paclitaxel

0.1

0.01

Camptothecine

0.1

0.01

Fenbendazole

10

10

Mebendazole

1

1

Albendazole

10

1

Norethindrone

100

100

Betamethasone

>100

100

Methylene Blue

>100

10

Rotenone

1

1

Daunorubicin

1

0.1

Chelidonine

10

10

Alexidine

10

10

Podophyllotoxin

0.1

0.1

  1. The concentration that was toxic to 50% of the cells (TC50) and the concentration that significantly reduced tau levels (IC) was determined for several compounds identified from screening
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Molecular Neurodegeneration

ISSN: 1750-1326