Skip to main content

Advertisement

Table 2 Therapeutic window for most favorable candidate compounds

From: Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

  TC50 (μM) IC (μM)
Paclitaxel 0.1 0.01
Camptothecine 0.1 0.01
Fenbendazole 10 10
Mebendazole 1 1
Albendazole 10 1
Norethindrone 100 100
Betamethasone >100 100
Methylene Blue >100 10
Rotenone 1 1
Daunorubicin 1 0.1
Chelidonine 10 10
Alexidine 10 10
Podophyllotoxin 0.1 0.1
  1. The concentration that was toxic to 50% of the cells (TC50) and the concentration that significantly reduced tau levels (IC) was determined for several compounds identified from screening