Skip to main content
Figure 1 | Molecular Neurodegeneration

Figure 1

From: Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau

Figure 1

The effects of PTEN on phosphorylation of the FTDP-17 mutant tau. A. Schematic drawing of the FTDP-17 mutant tau, T40RW, and major phosphorylation sites by various kinases. The missense mutation of Arg to Trp at position 406 is labeled by a star. The examined phosphorylation sites are in bold. Kinases are abbreviated as follows: M, MAPK; G, GSK-3; C5, CDK5; A, PKA; C, PKC; PK, phosphorylase kinase. The four repeats of microtubule-binding domain (MBD) are shown as the filled areas. B. Vector, wild-type (PTEN-WT) or the phosphatase null mutant PTEN (PTEN-CG) transfected COS-7 cells were analyzed by Western blotting using phospho-tau specific antibodies as indicated. C. Levels of phospho-tau were quantified and normalized to the total tau level. Error bars indicate means ± SE, n = 4, *p < 0.02 and **p < 0.05.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326