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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau

Figure 4

The phosphatase activity null PTEN leads to formation of visible tau aggregates in cells. COS-7 cells stably expressing the FTDP-17 mutant tau were transfected with pIRES-EGFP (A-D), pIRES-EGFP-PTENwt (E-H) or pIRES-EGFP-PTENcg (I-L). Expression of EGFP control (A), PTEN-WT (E) or PTEN-CG (I) was visualized based on the EGFP fluorescence. Cells were further immunostained to detect tau (B,F,J) and α-tubulin (C,G,K). Fluorescence micrographs were visualized and recorded by fluorescence microscope. D, H, and L are merged images of tau and α-tubulin immunostaining.

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Molecular Neurodegeneration

ISSN: 1750-1326