Figure 2

Analysis of age-related neuronal loss in the mouse dentate gyrus. Mean number of CR positive neurons or total neurons were estimated in both wild-type (5 month-old, n = 4; 18 month-old, n = 5) and NSE73a transgenic mice (5 month-old, n = 3; 18 month-old, n = 3). A) Mean number of CR positive neurons (+/- SD) estimated in the SGZ and hilus of the mouse dentate gyrus. Based on two-way ANOVA, There was a statistical difference between two age groups (P = 0.003), but there was no difference between two genotypes (P = 0.144), and there was not a statistically significant interaction between genotype and age (P = 0.07). B) Mean number of NeuN positive neurons (+/- SD) estimated in the same region as in (A). Based on two-way ANOVA, There was not a statistical difference between two age groups (P = 0.142), not a difference between two genotypes (P = 0.076), and not a significant interaction between genotype and age (P = 0.266).