Figure 5
Selective SNc neurodegeneration induced by rotenone and the rescuing effect of piceid. A) Coronal sections from the rostral to caudal dopaminergic area containing neurons in the SNc were depicted by H&E staining. B) Representative TH-immunostained from coronal sections containing the SNc regions. C) Quantification of the TH-immunoreactive neurons based on the scans of every 10th section of the striatum (5 sections/animal × 5 animals per group) using Scion Image (Version 4.0.3.2 Scion Corporation, MD). Vehicle: sunflower oil + 0.5% CMC-Na 10; Pic: piceid (80 mg/kg/d); Rot: rotenone (2.0 mg/kg/d). “**” indicates P < 0.01 as compared to the piceid treatment group.