Figure 1
From: Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice
Aged DJ-1 -/- mice exhibit reduced spontaneous activity in the open field. (A-H) Evaluation of DJ-1-/- mice and wild-type controls at the age of 18–25 months (+/+: n = 17, -/-: n = 15) in the open field for 15 min. Two arrays measured horizontal movements (A-D), and one array measured vertical movements (rearing on hind legs) (E-G). Repeated sequential breakings of the same beam are scored as occurrences of stereotyped behaviors (scratching, grooming, etc.) (H). DJ-1-/- mice show significantly reduced horizontal activity, horizontal movements and stereotypy (p < 0.05). (I) DJ-1-/- and wild-type control mice at the age of 22–25 months show similar latencies to fall off an accelerating rotating rod during 3 trials (+/+: n = 9, -/-: n = 8, p > 0.05). (J and K) DJ-1-/- and wild-type mice at the age of 22–25 months show similar acoustic startle responses to 100 dB noise alone (+/+: 33.5 ± 6.7, n = 9, -/-: 48.5 ± 15.1, n = 6, p > 0.05), 100 dB noise with 80 dB PPI (+/+: 13.7 ± 3.1, n = 9, -/-: 22.8 ± 7.5, n = 6, p > 0.05) and %PPI (+/+: 52.9 ± 9.9, n = 9, -/-: 38.2 ± 16.1, n = 6, p > 0.05). Data in all panels are expressed as mean ± SEM. Asterisk denotes statistical significance (*p < 0.05).