Figure 3

Morris water maze. A. Repeated measures ANOVA on latency to find the platform during acquisition shows that overall the difference between treatment groups was not significant (P = 0.12). However, naïve animals took fewer trials to learn the location of the platform than AAV treatment groups, reaching a minimum latency by day 3. BRI-Aβ40+42 animals had a noticeably higher latency on day 3 of acquisition than other groups. B. BRI-Aβ40+42 animals had the highest mean latency over all 20 trials of all treatment groups (ANOVA P = 0.07). C. Repeated measures ANOVA on pathlength to find the platform during acquisition shows that overall the difference between treatment groups was not significant (P = 0.061). D. BRI-Aβ40+42 animals took a significantly longer pathlength to find the platform over all 20 trials (ANOVA P = 0.02; BRI-Aβ40+42 > naïve, ** p < 0.01). E, F. Animals were put through a probe trial 24 hr after the last training trial. BRI-Aβ40+42 animals showed a non-significant reduction in time (ANOVA P = 0.2) and distance (ANOVA P = 0.13) spent in the target quadrant.