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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels

Figure 4

A. Passive avoidance. There was no difference in baseline latencies between the treatment groups (ANOVA P = 0.97) but at 24 hr BRI-Aβ40 animals had a reduced latency to re-enter the dark chamber compared to naïve controls (ANOVA P = 0.03; BRI-Aβ40 < naive, *p < 0.05). B, C. Novel object recognition. At 3 months post-injection BRI-Aβ42, BRI-Aβ40+42 and APPsw animals spent less total time (O1+O2+O3+N) exploring than naïve controls (B) but still explored the novel object (N) more than the familiar object, O3 (C). Total exploration time: ANOVA P = 0.003; APPsw < naive, p < 0.01, BRI-Aβ42 < naïve, p < 0.05.

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Molecular Neurodegeneration

ISSN: 1750-1326