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Figure 4 | Molecular Neurodegeneration

Figure 4

From: ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

Figure 4

ApoER2 and APP colocalization in hippocampal neurons. Primary cortical neurons were co-transfected with APP-Myc and ApoER2-HA and the receptors immunodetected in non-permeabilized (A) and permeabilized (B) cells using anti-Myc and anti-HA antibodies (C) Hippocampal primary neurons were permeabilized and labeled for total APP and ApoER2 with anti-APP(6E10) and C-terminal anti-ApoER2, respectively. APP695-Myc and ApoER2-HA partially co-localize at the soma surface (A, arrows) and within neuronal processes (arrowheads). A strong co-localization of APP and ApoER2 in a perinuclear region of permeabilized cells for both overexpressed (B) and endogenous levels (C) was evidenced.

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