Figure 6From: Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomersImmunolabeling characteristics of OC in an AD case and preabsorption controls. Extensive OC labeling was observed in the hippocampus (A), subiculum (B) and frontal cortex (C) in AD. A higher magnification photograph illustrates that OC positive deposits were dense and consisted of fine fibrillar material (D). Preabsorption with a 100-fold concentration of OC antigen leads to a significant reduction in immunolabeling in the frontal cortex (E &F). Significant overlap was observed between OC positive immunoreactivity (Red – G) and LOC positive immunoreactivity (Green-H) suggesting that the two antibodies recognize similar deposits (Overlap is yellow – I). Magnification in A, B, C – 1.25×, D – 20×, E, F – 4× and G, H, I – 40×.Back to article page