Figure 2

In the neuroprotection study, NTN-c17.2 grafts protected SN dopaminergic neurons in a 6-OHDA model of PD. A-D, TH immunohistochemistry showed the grafting of NTN-c17.2 cells (B) prevented the loss of dopaminergic neurons in the SN, while the grafts of Mock-c17.2 cells (C) and treatment with PBS (D) could not prevent the loss of dopaminergic neurons. E, Quantification of the number of TH-positive neurons in SN under the indicated experimental conditions. The number of TH-positive cells was counted in 7 serial sections of the SN. Values represent the mean ± SEM (n = 5). *#P < 0.05. The lesioned SN grafted with NTN-c17.2 cells was compared with samples from animals grafted with Mock-c17.2 cells or injected with PBS, as determined by one-way ANOVA (significant effect of treatment, p < 0.05). Scale bars: (in D) A-D, 250 μm.