Figure 1
From: Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease
Isoprostanes localization in AD and control brain. In adjacent serial sections of hippocampus of AD cases, neurons are intensely labeled with antisera against 13,14-dihydro 15-keto PGF2α (A) and 8-iso-PGF2α (C). AT8 recognizes NFT in the same field (E). In adjacent serial sections from an age-matched control, neuronal levels of 13,14-dihydro 15-keto PGF2α (B) and 8-iso-PGF2α (D) are significantly lower. Only a few NFT recognized by AT8 are present in the control. (*) marks landmark vessels in series (A,C,E) and (B,D,F). Scale bar = 50 μm.