Isoprostanes localization in AD and control brain. In adjacent serial sections of hippocampus of AD cases, neurons are intensely labeled with antisera against 13,14-dihydro 15-keto PGF2α (A) and 8-iso-PGF2α (C). AT8 recognizes NFT in the same field (E). In adjacent serial sections from an age-matched control, neuronal levels of 13,14-dihydro 15-keto PGF2α (B) and 8-iso-PGF2α (D) are significantly lower. Only a few NFT recognized by AT8 are present in the control. (*) marks landmark vessels in series (A,C,E) and (B,D,F). Scale bar = 50 μm.