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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding

Figure 5

Phorbol-stimulated sAPPα secretion is not modulated through Eve-1. HEK293–695 were transiently transfected with either Eve1-b or Eve1-c. Empty vector was used as control (Cont). Cells were treated with PDBu and processed as above. (A) Representative Western blot for sAPPα in the absence (-) or presence (+) of PDBu. (B) Quantification of 3 such experiments.

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Molecular Neurodegeneration

ISSN: 1750-1326