Figure 2From: Differential expression of interferon responsive genes in rodent models of transmissible spongiform encephalopathy diseaseExpression level of GFAP in four different models of amyloid disease. Pooled samples of total RNA isolated from the whole brains of diseased or age-matched control animals were used to determine relative GFAP expression levels by quantitative real-time PCR. The histograms represent the average of the means of three independent quantitative real-time PCR reactions, done in duplicate, ± standard deviation. All plotted data represent expression levels in diseased animals relative to gene expression levels in age and strain-matched control animals. A statistically significant increase in GFAP expression was observed in all terminal disease models (p = 3.44E-5 for Alzheimer's model, p = 0.000364 for VM BSE mice, p = 3.24E-5 for Hamster 263K 56 IC, p = 0.0068 for Hamster 263K IP, and p = 0.0014 for C57BL/6 ME7 mice).Back to article page