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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease

Figure 3

Plaque analysis of 18-month-old APP and APP/Snca-/- animals. A. Sections were stained with 6E10 antibody or thioflavine S as indicated. 6E10 staining revealed the total plaque load while thioflavine S detected mature plaques only. The plaque density is much higher in mice lacking α-synuclein when compared to APP controls. Scale bar: 100 μm. B. Bar graph indicating the density of plaques per square area. The plaque density in the APP/Snca-/- animals exceeds that of the APP animals by 3–4 fold. N = 4, ***p < 0.001

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