Figure 3From: Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's diseaseLack of progressive locomotor deficits in the striatal model. In the striatal model, locomotor activity in the open field test is normal at 6 and 12 months, demonstrating cell-autonomous accumulation of mhtt aggregates in MSNs are not sufficient to elicit a motor deficit.Back to article page