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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Novel action of apolipoprotein E (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons

Figure 6

Dimerization of apoE3 by disulfide bonds causes the difference in apoE isoform-specific binding affinity. EM and apoE3 (or apoE4) were incubated in the presence or absence of 5% β-mercaptoethanol for 1 h and EM-PC concentrations and the number of apoE molecules in the apoE-EM complex was determined as described in the Experimental Procedures. Data are means ± S.E. of three samples. *p < 0.001. Three independent experiments showed similar results.

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Molecular Neurodegeneration

ISSN: 1750-1326