Figure 3

Effects of Dimebon on NMDA-evoked currents. (A) Representative traces of NMDA-evoked current recorded from DIV9-10 WT and YAC128 MSN. The white bar represents application of 100 μM NMDA in the presence of 50 μM glycine and black bar represents application of 1 μM, 10 μM and 50 μM Dimebon as indicated. (B) Dose-dependence of Dimebon block. The peak NMDA-induced currents were normalized to the peak NMDA-induced currents in the same cell in the absence of Dimebon. The normalized data at each Dimebon concentration were averaged from several experiments and shown as mean ± SE (n = 8 for WT and n = 9 for YAC128 MSN). The IC50 = 10 μM for WT and YAC128 MSN.