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Table 1 Effects of Dimebon on glutamate-induced apoptosis in WT and YAC128 MSN.

From: Evaluation of Dimebon in cellular model of Huntington's disease

 

WT (% TUNEL-positive)

YAC128 (% TUNEL-positive)

Drug treatment

0 μM glutamate

250 μM glutamate

0 μM glutamate

250 μM glutamate

Dimebon

        

5 μM

7.53 ± 2.15

(7.25 ± 1.11)a

24.14 ± 3.22

(26.26 ± 3.50)

7.78 ± 1.29

(10.93 ± 2.89)

47.35 ± 1.95

(54.53 ± 5.40)

10 μM

8.34 ± 1.40

(5.88 ± 0.62)

39.58 ± 5.01

(37.59 ± 3.71)

7.86 ± 1.21

(7.24 ± 0.92)

54.90 ± 7.17

(65.84 ± 6.27)

50 μM

7.14 ± 1.19

(5.88 ± 0.62)

34.50 ± 2.12

(37.59 ± 3.71)

6.19 ± 0.96

(7.24 ± 0.92)

41.08 ± 3.25*

(65.84 ± 6.27)

  1. The fraction of apoptotic (TUNEL-positive) neurons is shown for wild type (WT) and YAC128 MSN without glutamate application and following application of 250 μM glutamate for 7 h. The experiments were conduced in the presence of 5, 10 and 50 μM Dimebon as indicated.
  2. aThe number in parenthesis is the untreated control cells in the same batch of MSN culture.
  3. *P < 0.05, compared with control cells and show protective effect.