From: Evaluation of Dimebon in cellular model of Huntington's disease
WT (% TUNEL-positive) | YAC128 (% TUNEL-positive) | |||||||
---|---|---|---|---|---|---|---|---|
Drug treatment | 0 μM glutamate | 250 μM glutamate | 0 μM glutamate | 250 μM glutamate | ||||
Dimebon | ||||||||
5 μM | 7.53 ± 2.15 | (7.25 ± 1.11)a | 24.14 ± 3.22 | (26.26 ± 3.50) | 7.78 ± 1.29 | (10.93 ± 2.89) | 47.35 ± 1.95 | (54.53 ± 5.40) |
10 μM | 8.34 ± 1.40 | (5.88 ± 0.62) | 39.58 ± 5.01 | (37.59 ± 3.71) | 7.86 ± 1.21 | (7.24 ± 0.92) | 54.90 ± 7.17 | (65.84 ± 6.27) |
50 μM | 7.14 ± 1.19 | (5.88 ± 0.62) | 34.50 ± 2.12 | (37.59 ± 3.71) | 6.19 ± 0.96 | (7.24 ± 0.92) | 41.08 ± 3.25* | (65.84 ± 6.27) |