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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin

Figure 1

Vitronectin deposits in senile plaques of Alzheimer disease brain. Upper panel: senile plaques of AD brain visualized with the OC antibody (green) and the 6E10 antibody against Aβ (red). Lower panel: vitronectin (green) reactivity shows extensive overlap with OC reactivity (red), suggesting that vitronectin is deposited at sites of amyloid formation. Co-localization appears as yellow-orange color, while lipofuscin autofluorescence is seen predominantly in the red channel. Nuclei were visualized with DAPI (blue). Scale bar = 10 μm.

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