TY - JOUR AU - Lewis, Jada AU - Melrose, Heather AU - Bumcrot, David AU - Hope, Andrew AU - Zehr, Cynthia AU - Lincoln, Sarah AU - Braithwaite, Adam AU - He, Zhen AU - Ogholikhan, Sina AU - Hinkle, Kelly AU - Kent, Caroline AU - Toudjarska, Ivanka AU - Charisse, Klaus AU - Braich, Ravi AU - Pandey, Rajendra K. AU - Heckman, Michael AU - Maraganore, Demetrius M. AU - Crook, Julia AU - Farrer, Matthew J. PY - 2008 DA - 2008/11/01 TI - In vivo silencing of alpha-synuclein using naked siRNA JO - Molecular Neurodegeneration SP - 19 VL - 3 IS - 1 AB - Overexpression of α-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characterized by diffuse Lewy Body disease post-mortem. Genetic variability in SNCA contributes to risk of idiopathic Parkinson's disease (PD), possibly as a result of overexpression. SNCA downregulation is therefore a valid therapeutic target for PD. SN - 1750-1326 UR - https://doi.org/10.1186/1750-1326-3-19 DO - 10.1186/1750-1326-3-19 ID - Lewis2008 ER -