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Table 1 Quantitative densitometry of SNCA in situ hybridization

From: In vivo silencing of alpha-synuclein using naked siRNA

 

SNCA densitometry R/L ratio

  

Brain region

PBS (N = 9)

Luciferase siRNA (N = 10)

SNCA siRNA (N = 11)

P-value: SNCA vs. Luciferase

P-value: SNCA vs. PBS

Cortex

0.92 (0.82 – 0.98)

0.90 (0.86 – 1.00)

0.27 (0.20 – 0.90)

0.036

0.067

CA1

1.02 (0.98 – 1.14)

0.97 (0.93 – 1.06)

0.35 (0.14 – 0.54)

<0.001

<0.001

CA2

1.02 (0.93 – 1.05)

1.01 (0.97 – 1.15)

0.42 (0.19 – 0.62)

<0.001

<0.001

CA3

1.15 (0.99 – 1.24)

1.09 (1.01 – 1.15)

0.27 (0.12 – 0.71)

<0.001

<0.001

DG

1.02 (0.99 – 1.11)

0.99 (0.94 – 1.04)

0.19 (0.10 – 0.68)

0.008

0.001

  1. Using densitometry to determine efficacy of SNCA siRNA, SNCA expression in the injected (PBS, luciferase siRNA or SNCA siRNA) right side was compared to the uninjected left side and compared across treatment groups. P-values were derived from Wilcoxon rank sum test and the sample median (25th percentile – 75th percentile) is given.
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Molecular Neurodegeneration

ISSN: 1750-1326