Table 2 Patient Information and Neuropathology Data
Case | Gender | Age at onset (yrs) | Age at death (yrs) | APOEGenotype | Brain Weight (g) | Frontal Atrophy | Neuronal Loss | Gliosis | CAA | *Avg CWP | *Avg Mature Plaques | *Avg Primitive Plaques | *Avg Diffuse Plaques | *Avg NFT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A79V-PSEN1 | F | 50 | 61 | 3/4 | 1060 | 2 | 2 | 2 | 0 | 0.00 | 8.67 | 43.67 | 65.33 | 9.00 |
A260V-PSEN1 | M | 40 | 46 | 2/3 | 1140 | 3 | 1/2 | 1/2 | 1 | 0.00 | 2.33 | 0.67 | 109.00 | 31.00 |
F105L-PSEN1 | F | 60 | 68 | 2/3 | 1070 | 2 | 2 | 2 | 1 | 0.00 | 1.00 | 0.00 | 78.67 | 17.00 |
Y115C-PSEN1 | M | 41 | 51 | 3/3 | 1026 | 2/3 | 2/3 | 2/3 | 1 | 0.00 | 0.67 | 8.67 | 70.67 | 31.33 |
A431E-PSEN1 | F | 35 | 43 | 3/3 | 764 PF | 3 | 2/3 | 2/3 | 2 | 46.33 | 11.67 | 5.00 | 42.00 | 55.33 |
V261F-PSEN1 | M | 36 | 47 | 3/3 | 950 | 2 | 2 | 1 | 3 | 36.33 | 0.67 | 0.00 | 2.00 | 49.00 |
N141I-PSEN2 | M | 42 | 57 | 3/4 | 1136 | 2 | 1/2 | 1/2 | 2 | 0.00 | 2.00 | 1.33 | 67.67 | 65.00 |
V261I-PSEN1 | F | 48 | 55 | 3/3 | 1185 | 1 | 2 | 2 | 2 | 49.00 | 1.00 | 0.00 | 1.67 | 0.00 |
M146L-PSEN1 | M | 47 | 52 | 3/3 | 1150 | 1 | 2 | 2 | 1 | 0.00 | 14.00 | 0.00 | 102.00 | 14.33 |
P264L-PSEN1 | F | 48 | 53 | 3/3 | 940 | 2 | 2 | 2 | 0 | 13.67 | 8.00 | 0.00 | 12.67 | 14.67 |
sporadic AD | M | 47 | 62 | 3/3 | 910 | 2 | 2/3 | 2/3 | 1 | 0.00 | 23.33 | 0.00 | 12.00 | 42.33 |
sporadic AD | M | 55 | 66 | 3/4 | 1325 | 1 | 2/3 | 2/3 | 1 | 0.00 | 11.67 | 0.00 | 30.67 | 6.33 |
sporadic AD | M | 58 | 73 | 3/4 | 1236 PF | 2 | 2 | 2 | 2 | 0.00 | 5.67 | 0.00 | 15.33 | 12.00 |
sporadic AD | F | 48 | 55 | 3/4 | 1100 | 3 | 2/3 | 2/3 | 0 | 0.00 | 36.67 | 0.00 | 21.33 | 55.33 |