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Table 2 Patient Information and Neuropathology Data

From: Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

Case Gender Age at onset (yrs) Age at death (yrs) APOEGenotype Brain Weight (g) Frontal Atrophy Neuronal Loss Gliosis CAA *Avg CWP *Avg Mature Plaques *Avg Primitive Plaques *Avg Diffuse Plaques *Avg NFT
A79V-PSEN1 F 50 61 3/4 1060 2 2 2 0 0.00 8.67 43.67 65.33 9.00
A260V-PSEN1 M 40 46 2/3 1140 3 1/2 1/2 1 0.00 2.33 0.67 109.00 31.00
F105L-PSEN1 F 60 68 2/3 1070 2 2 2 1 0.00 1.00 0.00 78.67 17.00
Y115C-PSEN1 M 41 51 3/3 1026 2/3 2/3 2/3 1 0.00 0.67 8.67 70.67 31.33
A431E-PSEN1 F 35 43 3/3 764 PF 3 2/3 2/3 2 46.33 11.67 5.00 42.00 55.33
V261F-PSEN1 M 36 47 3/3 950 2 2 1 3 36.33 0.67 0.00 2.00 49.00
N141I-PSEN2 M 42 57 3/4 1136 2 1/2 1/2 2 0.00 2.00 1.33 67.67 65.00
V261I-PSEN1 F 48 55 3/3 1185 1 2 2 2 49.00 1.00 0.00 1.67 0.00
M146L-PSEN1 M 47 52 3/3 1150 1 2 2 1 0.00 14.00 0.00 102.00 14.33
P264L-PSEN1 F 48 53 3/3 940 2 2 2 0 13.67 8.00 0.00 12.67 14.67
sporadic AD M 47 62 3/3 910 2 2/3 2/3 1 0.00 23.33 0.00 12.00 42.33
sporadic AD M 55 66 3/4 1325 1 2/3 2/3 1 0.00 11.67 0.00 30.67 6.33
sporadic AD M 58 73 3/4 1236 PF 2 2 2 2 0.00 5.67 0.00 15.33 12.00
sporadic AD F 48 55 3/4 1100 3 2/3 2/3 0 0.00 36.67 0.00 21.33 55.33
  1. *all counts are measured in mm2; yrs = years; APOE = apolipoprotein E; g = grams; CAA = cerebral amyloid angiopathy; avg = average; CWP = cotton wool plaques; NFT = neurofibrillary tangles; F = female; M = males; yrs = years; AD = Alzheimer's disease; PSEN = presenilin; PF = post-fixed; 0 = none; 1 = mild; 2 = moderate; 3 = severe;