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Figure 7 | Molecular Neurodegeneration

Figure 7

From: Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

Figure 7

Images of JC-1 staining of differentiated SH-SY5Y neural cells exposed to 50 nM rotenone for the indicated number of days. Green corresponds to monomeric JC-1 accumulating in low voltage mitochondria, and red corresponds to J-aggregates that form in highly energized mitochondria. Shown are representative examples of green/red image pairs at different rotenone exposure times. Cells with loss of red JC-1 aggregate staining were not observed at any rotenone exposure time point. Note the absence of neurites in the 21 days neurons.

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Molecular Neurodegeneration

ISSN: 1750-1326