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Table 1 Heparin Modulation of the Wnt-3a ligand Effect on the Survival of Hippocampal Neurons Exposed to the Aβ peptide

From: The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

Treatment Cell Survival (%)
Control 100.0 ± 6.1
Aβ 51.4 ± 2.9
Aβ + Wnt-3A 75.9 ± 4.3
Aβ + Wnt-3A + heparin 0.1 μg/ml 88.3 ± 6.0 *
Aβ + Wnt-3A + heparin 1.0 μg/ml 103.1 ± 8.5 *
  1. Values represent means ± s.d. of three experiments carried out in triplicate. Hippocampal neurons were pretreated with Wnt-3a ligand with or without heparin for 1 h previous to the addition of 5 mM Aβ1–40. Neurons were then incubated for 24 h and MTT reduction was determined. * Indicates P < 0.05 compared with respect to Aβ + Wnt-3a in a "T" test analyzed by the Sigma plot 2.0 program.