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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

Figure 2

27-OHC, but not 24-OHC, increases levels of APP and BACE1. Representative Western blots (a) and densitometric (b) analysis demonstrating increased levels of APP with 27-OHC. No changes were found in levels of APP with 24-OHC or 24-OHC+ 27-OHC treatment. BACE1 levels were unchanged with 24-OHC treatment but significantly increased with 27-OHC or a mixture of 24-OHC + 27-OHC. *p < 0.05, **p < 0.01 (One way ANOVA followed by Dunnett's multiple comparison test).

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Molecular Neurodegeneration

ISSN: 1750-1326