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Table 1 Variability in AO attributable to the CAG repeat length was assessed by linear regression using the logarithmically transformed AO as the dependent variable and SNP genotypes as independent variables.

From: PGC-1alphaas modifier of onset age in Huntington disease

Model R2 ΔR2 % additionally explained variance Pvalue
HD CAG 40–66 (n = 401) 0.729 -   < 0.0005
PGC-1alpha Polymorphis ms     
rs2970865 promoter region - - - -
rs2970866 promoter region - - - -
rs4383605 promoter region - - - -
rs2946386 promoter region - - - -
rs2970869 promoter region - - - -
rs17576121 promoter region - - - -
rs2970870 promoter region - - - -
rs7695542 promoter region - - - -
rs2970873 intron1 - - - -
rs2946385 intron2 - - - -
rs12374310 intron2 - - - -
rs7665116 intron2     
0,1,2   0.732 0.003 1.1 0.025
0,1,1   0.733 0.004 1.5 0.012
rs2970855 intron5 - - - -
rs2970848 intron7 0.731 - - 0.054
rs8192678 exon 8 - - - -
  1. R2 illustrates the relative improvement of the regression model when the genotypes are considered in addition to the CAG repeats; ΔR2 values quantify these differences. (-) indicates no increase in R2.