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Table 1 Variability in AO attributable to the CAG repeat length was assessed by linear regression using the logarithmically transformed AO as the dependent variable and SNP genotypes as independent variables.

From: PGC-1alphaas modifier of onset age in Huntington disease

Model

R2

ΔR2

% additionally explained variance

Pvalue

HD CAG 40–66 (n = 401)

0.729

-

 

< 0.0005

PGC-1alpha Polymorphis ms

    

rs2970865

promoter region

-

-

-

-

rs2970866

promoter region

-

-

-

-

rs4383605

promoter region

-

-

-

-

rs2946386

promoter region

-

-

-

-

rs2970869

promoter region

-

-

-

-

rs17576121

promoter region

-

-

-

-

rs2970870

promoter region

-

-

-

-

rs7695542

promoter region

-

-

-

-

rs2970873

intron1

-

-

-

-

rs2946385

intron2

-

-

-

-

rs12374310

intron2

-

-

-

-

rs7665116

intron2

    

0,1,2

 

0.732

0.003

1.1

0.025

0,1,1

 

0.733

0.004

1.5

0.012

rs2970855

intron5

-

-

-

-

rs2970848

intron7

0.731

-

-

0.054

rs8192678

exon 8

-

-

-

-

  1. R2 illustrates the relative improvement of the regression model when the genotypes are considered in addition to the CAG repeats; ΔR2 values quantify these differences. (-) indicates no increase in R2.
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Molecular Neurodegeneration

ISSN: 1750-1326