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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

Figure 5

Impaired aconitase activity and increased caspase 3 activation resulting from 72Q Htt-exon1 expression in differentiated cells. Aconitase activity determination in cell lysates one and two days after induction of mutant Htt expression with 500 nM RSL1 in proliferating (A) and differentiated (B) 72Q Htt-exon1 cells (white bars) compared to non-expressing cells (black bars). C: Increase in caspase 3/7 activity in cell lysates after induction of 72Q Htt-exon1 expression with 500 nM RSL1 in differentiated HN10 cells (white bars). Expression of the wild-type 25Q Htt-exon1 decreases caspase 3/7 activity (black bars). All graphs: n = 3, * p < 0.05, ** p < 0.01.

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Molecular Neurodegeneration

ISSN: 1750-1326