All-you-can-eat: autophagy in neurodegeneration and neuroprotection

Table 1 Presence of autophagy related gene expression in neuronal tissue.

Gene	H. sapiens		M. musculus		R. norvegicus	Gene	D. melanogaster	Gene	C. elegans
	mRNA	Protein		AllenB
*ULK1*	[67]		[99, 100, 107]	Yes	[92]	*Atg1*	[97]	*unc-51*	WoBa [109, 110, 112, 113]
*ATG3*	[74]		[104]	Yes		*Atg4/Aut1*	[111]	*atg-3*
*ATG4*	[68]		[90]	Yes	[105]	*Aut2/Atg4*		*atg-4.1-2*	WoBa
*ATG5*			[60, 91, 93, 96]	Weak	[87]	*Atg5*		*atg-5/atgr-5*
*BECN1*	[59, 69]	[59, 65, 69]	[59, 81, 96]	Yes	[80, 94, 95, 106]	*Atg6*	[97]	*bec-1*	WoBa [116]
*PIK3C3*	[66]	[77]		Yes		*Vps34/Pi3K59F*		*vps-34/let-512*	[114]
*PIK3R4*	[71]			Weak		*Vps15/ird1*		*ZK930.1*
*UVRAG*	[72]			Yes
*AMBRA1*			[83]	n.a.
*ATG7*	[75]		[61, 96]	Weak	[75]	*Atg7*		*atg-7/atgr-7*
*MAP1LC3*		[58, 65]	[56, 60, 65, 79, 84, 86, 96]	Yes	[87–89, 95, 103, 106]		[97]	*lgg-2*
*GABARAP*	[78]			Yes	[89, 92]	*Atg8a*		*lgg-1*	WoBa
*GABARAPL2*	[78]			Yes	[89]
*ATG12*			[82, 96]	Weak	[87]	*Atg12*		*lgg-3*
*CHMP4B*			[85]	n.a.		*shrb/Vps32*	[108, 115]	*vps-32.1*	WoBa
*HSPA8*	[70]	[63, 73, 76]		Yes	[76, 98, 101]	*Hsc70-4*		*hsp-1*
*LAMP2*		[64]	[102]	Weak	[102, 103]

Examples of autophagy related gene expression in humans and common model organisms (mRNA and/or protein). For human, mouse, and rat genes the approved human gene symbol is used http://www.genenames.org, for D. melanogaster and C. elegans their respective gene symbols (if existent) are provided. (AllenB): Gene mRNA is detectable by hybridization as published in the Allen Brain Atlas http://www.brain-map.org; (WoBa): neuronal expression data available at WormBase http://www.wormbase.org; (n.a.): not available.

ISSN: 1750-1326