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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575

Figure 3

Representative example of the effect of LY-411575 treatment on neuritic curvature in APPswe/PS1dE9xYFP mice. Animals received daily oral administration of LY-411575 (5 mg/Kg) or vehicle for 3 weeks. These in vivo multiphoton images were taken before starting the treatment (session 1, A-LY-411575, C-vehicle) and after 3 weeks of treatment (session 4, B-LY-411575 and D-vehicle). Each image is a maximum intensity projection of a small volume of the brain. Individual neurites are traced for the curvature measurements before and after treatment. Neurons are green, blood vessels are blue, and dense-core Aβ plaques (red) were labeled by systemic injection of methoxy-XO4. Scale bar: 25 μm

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Molecular Neurodegeneration

ISSN: 1750-1326