Effects of acute apoE isoform exposure on ERK1/2 and JNK1/2 activation. Quantification of A) pERK/ERK rato and B) pJNK/JNK ratio in CA1 of apoE-deficient animals treated with 100 nM rhapoE isoforms (n = 6 for each). Representative western blots showing levels of pERK, ERK, pJNK, JNK, and actin. control (C, light grey), rhapoE2 (E2, medium grey), rhapoE3 (E3, dark grey), rhapoE4 (E4, black). Data expressed as mean ± SEM.