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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Nucleation of protein aggregation kinetics as a basis for genotype-phenotype correlations in polyglutamine diseases

Figure 3

Linear regression analysis of SCA1 and -2 based on the model. (A) A total of 221 SCA1 patients with expanded CAG repeats in the ataxin-1 gene was analyzed. Inspection of logarithmically transformed mean age-at-onset versus CAG size plots identified 40, 69 and 81 CAG repeats as relative outliers. These data were therefore excluded from further analysis. Logarithmically transformed mean age-of-onset versus CAG size was the best fit to a quadratic curve. A regression analysis of natural log-transformed (tA2 - tE2)1/2 against CAG size provided the best fit to a linear model (-0.0569x + 6.249) when tE2 = 170. (B) A total of 141 SCA2 patients with expanded CAG repeats in the ataxin-2 gene was analyzed. Inspection of logarithmically transformed mean age-at-onset versus CAG size plots identified 51 and 57 CAG repeats as relative outliers. These data were excluded from further analysis. Logarithmically transformed mean age-of-onset versus CAG size was best fit to a quadratic curve. A regression analysis of natural log-transformed (tA2 - tE2)1/2 against CAG size provided the best fit to a linear model (-0.1217x + 8.377) when tE2 = 80.

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