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Table 1 Parameters based on the model: In (tA2 - tE2)1/2 = In(a) - bx + ε

From: Nucleation of protein aggregation kinetics as a basis for genotype-phenotype correlations in polyglutamine diseases

  HD SCA1 SCA7 DRPLA SCA2 SCA6
% patients 98.42 97.74 97.87 96.70 98.58 93.94
t E 2 215 170 30 0 80 700
intercept (In(α)) 6.657 6.249 6.513 11.011 8.377 9.553
   ± SE 0.1432 0.1516 0.1697 0.7543 0.3160 0.4076
slope (-b) 0.0662 0.0569 0.0658 0.1247 0.1217 0.2567
   ± SE 0.00316 0.00298 0.00338 0.0116 0.00773 0.0181
F test 437.65 364.59 380.43 114.96 248.33 201.92
(P) 3.23E-61 4.13E-48 1.84E-46 1.58E-17 1.45E-32 1.23E-27
R 2 0.5854 0.6301 0.6764 0.5721 0.6445 0.6234
R2 * 0.5321 0.6259 0.6595 0.5721 0.6391 0.6012
  1. % patients = percent of patients comprised the model, SE = standard error, R2 = coefficient determination, R2 * = R2 derived from linear regression analysis of simple logarithmic transformation of age-of-onset without tE2.