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Table 1 PPARGC1A Block 2 Haplotypes and Age at Onset of HD

From: The gene coding for PGC-1α modifies age at onset in Huntington's Disease

Haplotype

Frequency

Score

P

0000

0.234

-2.766

0.0057

0001

0.139

2.633

0.0085

0011

0.080

0.038

0.9698

0111

0.324

-0.192

0.8479

1000

0.204

0.396

0.6923

  1. N = 389; adjusted for CAG repeat size on both alleles (HD and non-HD) and their interaction;
  2. P = 0.0161 for global haplotype statistics; block 2 haplotypes: 0, more common allele
  3. (+1302C, +1564C, +1704C, +2962C); 1, less common allele (+1302T, +1564T, +1704C, +2962T).
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Molecular Neurodegeneration

ISSN: 1750-1326