Table 2 PPARGC1A rs7665116 and Age at Onset in the HD Cohort
From: The gene coding for PGC-1α modifies age at onset in Huntington's Disease
rs7665116 genotype | |||||
|---|---|---|---|---|---|
Variable | A/A | A/G | G/G | P a | P b |
Sex, m/f | 155/157 | 53/72 | 7/5 | n.s. | n.s. |
HD CAG | 45.3 (5.5) | 45.2 (5.9) | 45.8 (2.8) | n.s. | n.s. |
Non-HD CAG | 18.3 (3.2) | 18.5 (3.5) | 17.7 (3.9) | n.s. | n.s. |
HD CAG*non-HD CAG | 828 (179) | 840 (210) | 809 (192) | n.s. | n.s. |
HD-onset, yearsc | 45.08 (1.43) | 48.75 (1.39) | 49.09 (1.22) | 0.0016 | 0.0003 |