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Table 2 PPARGC1A rs7665116 and Age at Onset in the HD Cohort

From: The gene coding for PGC-1α modifies age at onset in Huntington's Disease

  rs7665116 genotype   
Variable A/A A/G G/G P a P b
Sex, m/f 155/157 53/72 7/5 n.s. n.s.
HD CAG 45.3 (5.5) 45.2 (5.9) 45.8 (2.8) n.s. n.s.
Non-HD CAG 18.3 (3.2) 18.5 (3.5) 17.7 (3.9) n.s. n.s.
HD CAG*non-HD CAG 828 (179) 840 (210) 809 (192) n.s. n.s.
HD-onset, yearsc 45.08 (1.43) 48.75 (1.39) 49.09 (1.22) 0.0016 0.0003
  1. a additive model; b dominant model; c calculated from log-transformed years and adjusted for HD CAG and non-HD CAG repeat size and their product.