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Table 3 PPARGC1A rs6821591 and Age at Onset in the HD Cohort

From: The gene coding for PGC-1α modifies age at onset in Huntington's Disease

  Rs6821591 genotype   
Variable A/A A/G G/G P a P b
Sex, m/f 39/41 110/121 64/72 n.s. n.s.
HD CAG 45.2 (5.5) 44.8 (5.9) 46.1 (2.8) n.s. n.s.
Non-HD CAG 18.5 (5.4) 18.2 (3.9) 18.5 (7.5) n.s. n.s.
HD CAG*non-HD CAG 833 (158) 816 (170) 855 (228) n.s. n.s.
HD-onset, yearsc 44.1 (1.48) 46.6 (1.34) 46.9 (1.48) 0.0870 0.0295
  1. a additive model; b dominant model; c calculated from log-transformed years and adjusted for HD CAG and non-HD CAG repeat size and their product.