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Table 3 PPARGC1A rs6821591 and Age at Onset in the HD Cohort

From: The gene coding for PGC-1α modifies age at onset in Huntington's Disease

 

Rs6821591 genotype

  

Variable

A/A

A/G

G/G

P a

P b

Sex, m/f

39/41

110/121

64/72

n.s.

n.s.

HD CAG

45.2 (5.5)

44.8 (5.9)

46.1 (2.8)

n.s.

n.s.

Non-HD CAG

18.5 (5.4)

18.2 (3.9)

18.5 (7.5)

n.s.

n.s.

HD CAG*non-HD CAG

833 (158)

816 (170)

855 (228)

n.s.

n.s.

HD-onset, yearsc

44.1 (1.48)

46.6 (1.34)

46.9 (1.48)

0.0870

0.0295

  1. a additive model; b dominant model; c calculated from log-transformed years and adjusted for HD CAG and non-HD CAG repeat size and their product.