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Table 4 PPARGC1A rs7665116 and rs6821591 Haplotypes and Age-at-Onset of HD

From: The gene coding for PGC-1α modifies age at onset in Huntington's Disease

Haplotype Frequency Score P
00 0.427 -2.065 0.0389
01 0.406 -0.583 0.5600
10 0.010 0.812 0.4170
11 0.157 3.404 0.0007
  1. N = 447; adjusted for CAG repeat size on both alleles (HD and non-HD) and their interaction;
  2. P = 0.0056 for global haplotype statistics; block 2 haplotypes: 0, more common allele
  3. (rs7665116A, rs6821591C); 1, less common allele (rs7665116G, rs6821591T).