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Table 4 PPARGC1A rs7665116 and rs6821591 Haplotypes and Age-at-Onset of HD

From: The gene coding for PGC-1α modifies age at onset in Huntington's Disease

Haplotype

Frequency

Score

P

00

0.427

-2.065

0.0389

01

0.406

-0.583

0.5600

10

0.010

0.812

0.4170

11

0.157

3.404

0.0007

  1. N = 447; adjusted for CAG repeat size on both alleles (HD and non-HD) and their interaction;
  2. P = 0.0056 for global haplotype statistics; block 2 haplotypes: 0, more common allele
  3. (rs7665116A, rs6821591C); 1, less common allele (rs7665116G, rs6821591T).
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Molecular Neurodegeneration

ISSN: 1750-1326