In hippocampal neurons, FOXO3a is present at similar levels in control (A), and cases diagnosed with LBD (B). Cortical Lewy bodies, however, exhibit intense immunolabeling for FOXO3a, in cortical regions from all cases diagnosed with pure LBD (C), and with AD/LBD (D). Lewy neurites also accumulate FOXO3a (E). Significantly, cortical Lewy bodies also demonstrate increased 14-3-3 (F). Scale bars = 50 μm (A-C); 20 μm (D-F).