Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide

Table 1 Summary of age, gender, PMI and Aβ load in the AD and age-matched controls brain tissues.

Sample	Age (years)	Gender (M/F)	PMI (hrs)	Aβ Load (scale 0–8)
AD				C	F	T
1	74	M	N/A	2	8	8
2	72	M	18	0	8	8
3	87	M	4	0	4	6
4	83	M	5	0	8	8
5	84	M	2	1	4	4
6	88	M	N/A	0	8	8
7	72	M	2	3	8	8
8	79	M	23	0	8	8
9	92	M	10	0	6	6
10	82	F	4	2	8	8
11	83	F	2	2	7	7
12	85	F	3	0	7	5
Average	81.7 +/- 6.3		7.3	0.8	7	7
Controls
1	67	M	3	0	0	0
2	74	M	N/A	0	2	0
3	87	F	24	0	3	3
4	62	M	N/A	0	0	0
5	89	M	6	0	0	0
6	85	M	48	0	4	3
7	87	F	4	0	0	0
8	78	F	6	0	4	3
9	87	M	12	0	2	0
Average	79.5 +/- 9.9		14.7	0	1.7	1

Table summarizes the post mortem intervals (PMI) and the Aβ load for each brain tissue specimen used. The plaque counts were performed in specific areas using semi-quantitative measures generated using CERAD methodology. They are purely estimates of pathology on a scale of 0–8. There was no statistically significant difference in age between groups by T-test. In the AD group, the majority is males since the samples were obtained from a VA hospital.
C = Cerebellum; F = Frontal cortex; T = Temporal cortex; Gender: M = Male; F = Female; PMI = post mortem interval.

ISSN: 1750-1326