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Table 1 ApoE-associated proteins identified by LC-MS/MS analysis

From: Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

Protein Intracellular localization Function
   Solute carrier family 25 (mitochondrial carrier, Aralar) member 12 Mitochondria Calcium-dependent mitochondrial aspartate and glutamate carrier
   Ubiquinol cytochrome c reductase core protein 1 Mitochondria Mitochondrial electron transport
* Ubiquinol cytochrome c reductase core protein 2 (UQCRC2) Mitochondria Mitochondrial electron transport
* Cytochrome C1 Mitochondria Mitochondrial electron transport
   Cytochrome oxidase subunit II Mitochondria Mitochondrial electron transport
* Cytochrome c oxidase subunit IV isoform 1 (COX IV1) Mitochondria Mitochondrial electron transport
   ATP synthase, H+ transporting, mitochondrial F1 complex, α subunit, isoform 1 Mitochondria ATP synthesis
   ATP synthase, H+ transporting, mitochondrial F1 complex, β subunit Mitochondria ATP synthesis
   ATP synthase, H+ transporting, mitochondrial F1 complex, δ subunit Mitochondria ATP synthesis
   Methylenetetrahydrofolate dehydrogenase (NADP+ dependent)- 1 like Mitochondria Folic acid and derivative biosynthetic process
   Syntaxin binding protein 1 Cytoplasm Modulates exocytosis of dense-core granules
   Nonmuscle myosin heavy chain Cytoplasm Actin filament-based movement
   Tubulin, alpha 1A Cytoplasm Constituent of microtubules
   RAB3A, member RAS oncogene family Cytoplasm Involved in exocytosis by regulating a late step in synaptic vesicle fusion.
   Progesterone receptor membrane component 1 Plasma membrane Receptor for progesterone
   Cardiotrophin-like cytokine factor 1 Extracellular space Cell surface receptor linked signal transduction
  1. ApoE4-associated protein bands that were detected with SDS-PAGE were prepared and analyzed as described in the Methods. Asterisks (*) show the apoE-binding proteins identified and characterized in this study.