Table 1 ApoE-associated proteins identified by LC-MS/MS analysis
Protein | Intracellular localization | Function |
|---|---|---|
Solute carrier family 25 (mitochondrial carrier, Aralar) member 12 | Mitochondria | Calcium-dependent mitochondrial aspartate and glutamate carrier |
Ubiquinol cytochrome c reductase core protein 1 | Mitochondria | Mitochondrial electron transport |
* Ubiquinol cytochrome c reductase core protein 2 (UQCRC2) | Mitochondria | Mitochondrial electron transport |
* Cytochrome C1 | Mitochondria | Mitochondrial electron transport |
Cytochrome oxidase subunit II | Mitochondria | Mitochondrial electron transport |
* Cytochrome c oxidase subunit IV isoform 1 (COX IV1) | Mitochondria | Mitochondrial electron transport |
ATP synthase, H+ transporting, mitochondrial F1 complex, α subunit, isoform 1 | Mitochondria | ATP synthesis |
ATP synthase, H+ transporting, mitochondrial F1 complex, β subunit | Mitochondria | ATP synthesis |
ATP synthase, H+ transporting, mitochondrial F1 complex, δ subunit | Mitochondria | ATP synthesis |
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent)- 1 like | Mitochondria | Folic acid and derivative biosynthetic process |
Syntaxin binding protein 1 | Cytoplasm | Modulates exocytosis of dense-core granules |
Nonmuscle myosin heavy chain | Cytoplasm | Actin filament-based movement |
Tubulin, alpha 1A | Cytoplasm | Constituent of microtubules |
RAB3A, member RAS oncogene family | Cytoplasm | Involved in exocytosis by regulating a late step in synaptic vesicle fusion. |
Progesterone receptor membrane component 1 | Plasma membrane | Receptor for progesterone |
Cardiotrophin-like cytokine factor 1 | Extracellular space | Cell surface receptor linked signal transduction |