Skip to main content
Figure 5 | Molecular Neurodegeneration

Figure 5

From: Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance

Figure 5

Distribution across mtDNA of inhibition of PCR amplification from treatment with hOGG1 as a function of donor age. mtDNA's from CTL and sPD brains were treated with hOGG1 and amplified with qPCR and primer pairs A-H. Shown are the proportional amplification for each sample and each primer pair. sPD samples showed (with one exception) an age-related in increase of hOGG1 sensitivity not seen in CTL samples. Donor ages for each sample are shown on the right.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326