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Table 1 C. elegans transgenic models for human neurodegenerative diseases.

From: What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?

Neurodegeneration-associated protein Transgene expression Promoter Sequence References
Huntingtin::polyQ chemosensory neurons osm-10 Faber et al [3]
  mechanosensory neurons mec-3 Parker et al [11]
  muscle unc-54 Wang et al [19]
DRPLAP::polyQ muscle unc-54 Yamanaka et al [18]
GFP::polyQ muscle unc-54 Saytal et al [14]
  pan-neuronal rgef-1 Brignull et al [82]
α-synuclein pan-neuronal aex-3 Lakso et al [21]
  dopaminergic neurons dat-1  
  dopaminergic neurons dat-1 Cao et al [22]
  dopaminergic neurons dat-1 Kuwahara et al [23]
  pan-neuronal unc-51 Kuwahara et al [25]
α-synuclein::GFP muscle unc-54 Hamamichi et al [26]
α-synuclein::YFP muscle unc-54 van Ham et al [27]
β-amyloid peptide muscle unc-54 Link [31]
  inducibe muscle myo-3 Link et al [38]
  inducible pan-neuronal snb-1 Wu et al [39]
tau pan-neuronal aex-3 Kraemer et al [50]
  mechanosensory neurons mec-7 Miyasaka et al [57]
  pan-neuronal rgef-1 Brandt et al [58]
SOD1 muscle myo-3 Oeda et al [60]
  heat shock inducible hsp-16.2  
  pan-neuronal snb-1 Wang et al [61]
SOD1::YFP muscle unc-54 Gidalevitz et al [62]
LRRK2 pan-neuronal snb-1 Saha et al [63]
mouse prion protein muscle unc-54 Park and Li [64]