Table 1 C. elegans transgenic models for human neurodegenerative diseases.
Neurodegeneration-associated protein | Transgene expression | Promoter Sequence | References |
|---|---|---|---|
Huntingtin::polyQ | chemosensory neurons | osm-10 | Faber et al [3] |
| Â | mechanosensory neurons | mec-3 | Parker et al [11] |
| Â | muscle | unc-54 | Wang et al [19] |
DRPLAP::polyQ | muscle | unc-54 | Yamanaka et al [18] |
GFP::polyQ | muscle | unc-54 | Saytal et al [14] |
| Â | pan-neuronal | rgef-1 | Brignull et al [82] |
α-synuclein | pan-neuronal | aex-3 | Lakso et al [21] |
| Â | dopaminergic neurons | dat-1 | Â |
| Â | dopaminergic neurons | dat-1 | Cao et al [22] |
| Â | dopaminergic neurons | dat-1 | Kuwahara et al [23] |
| Â | pan-neuronal | unc-51 | Kuwahara et al [25] |
α-synuclein::GFP | muscle | unc-54 | Hamamichi et al [26] |
α-synuclein::YFP | muscle | unc-54 | van Ham et al [27] |
β-amyloid peptide | muscle | unc-54 | Link [31] |
| Â | inducibe muscle | myo-3 | Link et al [38] |
| Â | inducible pan-neuronal | snb-1 | Wu et al [39] |
tau | pan-neuronal | aex-3 | Kraemer et al [50] |
| Â | mechanosensory neurons | mec-7 | Miyasaka et al [57] |
| Â | pan-neuronal | rgef-1 | Brandt et al [58] |
SOD1 | muscle | myo-3 | Oeda et al [60] |
| Â | heat shock inducible | hsp-16.2 | Â |
| Â | pan-neuronal | snb-1 | Wang et al [61] |
SOD1::YFP | muscle | unc-54 | Gidalevitz et al [62] |
LRRK2 | pan-neuronal | snb-1 | Saha et al [63] |
mouse prion protein | muscle | unc-54 | Park and Li [64] |