Figure 3
From: Novel cerebrovascular pathology in mice fed a high cholesterol diet
Abnormal vascular morphologies in C57BL/6J and LDLR-/- mice fed a high- cholesterol diet. Anti-collagen IV immunoperoxidase-stained microvessels in the hippocampus of one year old C57BL/6J (A, B, C), or LDLR-/- mice (D, E, F) fed a HCD for 10 months. Degenerating vascular segments are indicated by arrowheads in panels A and F. Typical string vessels are indicated by arrows in panels D and E. Panels B and C show dysmorphic and abnormally twisted vessels. Scale bar = 50 μm.